Mathematical Modeling of the Temperature Rise in a Thin Cell Culture Exposed to High Frequency Electromagnetic Irradiation

摘要

This report describes a mathematical model to predict the temperature increase in a thin layer of tissue culture exposed to electromagnetic energy at a frequency of 35 gigahertz (GHz). The goal of the modeling effort was to compare the calculated temperature rise with experimental valves obtained with mouse microphage cell cultures using an infrared camera. The expected temperature increase was calculated using a commercial finite difference time domain code (FDTD). Two problems arise when using FDTD to simulate high frequency electromagnetic radiation of a thin culture to obtain temperature information important to biologists: small time step (necessitating long simulation time) and extrapolation of temperature from specific absorption rates (SARs). In this paper we describe our numerical calculations and compare their results with experimental observations.