Potential Therapeutic Uses of p19ARF Mimics in Mammary Tumorigenesis; Final rept. 15 Jul 2004-14 Jul 2005

摘要

Since many breast tumors have deregulated c-Myc we hypothesize that an ARF mimic would be a valuable therapeutic agent for breast cancer to inhibit c-Myc-induced transformation/tumorigenesis without inhibiting normal cell proliferation or apoptosis. To test this hypothesize we will generate the reagents and establish the assays for the high throughput screening of chemical compounds that mimic ARF and analyze the candidate chemical compounds identified by the screen in molecular and biological assays. If successful, these studies would directly lead to a therapeutic agent to inhibit breast tumors that are known to harbor deregulated/elevated c-Myc.