Modulation of TRAIL Cytotoxicity by Amiloride in Prostate Cancer.

机译：阿米洛利对前列腺癌TRaIL细胞毒性的调节作用。

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The challenge today is to develop a cytotoxic agent that selectively induces cytotoxicity in prostate cancer cells but avoids significant toxicity to the normal tissues. In this study, we will develop a novel strategy by using TRAIL in combination with amiloride.

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Kim, K. M.; Kim, Y.;
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年度 2006
页码 1-17
总页数 17
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Proteins; Therapy; Anthoxanthin pigments; Prostate cancer; Tissues(Biology); Apoptosis; Drugs; Cells(Biology); Cytotoxins; Ligands; Quercetin; Cytotoxicity; Trail(Tumor necrosis factor-related apoptosis-inducing ligand); Pi3k; Amiloride; Na plus/h plus; Du-145; Akt; Pdk-1; Her-2/neu;

机译：蛋白质;治疗; anthoxanthin色素;前列腺癌;组织（生物学）;细胞凋亡;药物;细胞（生物学）;细胞毒素;配体;槲皮素;细胞毒性; Trail（肿瘤坏死因子相关凋亡诱导配体）; pi3k; amiloride; Na加/ h加; Du-145; akt; pdk-1; Her-2 / neu;

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专利

1. Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. [J] . Liu X, Elojeimy S, El-Zawahry AM, Molecular therapy: the journal of the American Society of Gene Therapy . 2006,第5期

机译：神经酰胺代谢的调节增强了前列腺癌中病毒蛋白凋亡素的细胞毒性。
2. Change in serum prostate-specific antigen as a marker of response to cytotoxic therapy for hormone-refractory prostate cancer. [J] . Smith DC, Dunn RL, Strawderman MS, Journal of Clinical Oncology . 1998,第5期

机译：血清前列腺特异性抗原的变化，作为对激素难治性前列腺癌的细胞毒性治疗反应的标志物。
3. Cytotoxic effects of camptothecin and cisplatin combined with tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) in a model of primary culture of non-small cell lung cancer. [J] . Frese S, Schuller A, Frese Schaper M, Anticancer Research: International Journal of Cancer Research and Treatment . 2009,第8期

机译：喜树碱和顺铂联合肿瘤坏死因子相关的凋亡诱导配体（Apo2L / TRAIL）在非小细胞肺癌原代培养模型中的细胞毒性作用。
4. Evaluation of the cytotoxic effect of PLGA coated iron oxide nanoparticles as 5-fluorouracil carrier on DU 145 human prostate carcinoma cell line [C] . Khoei S., Azarian M., Khoee S., 2012 International Conference on Enabling Science and Nanotechnology . 2012

机译：评价PLGA包覆的氧化铁纳米颗粒作为5-氟尿嘧啶载体对DU 145人前列腺癌细胞系的细胞毒性作用
5. Molecular interactions between galectin-3 and prostate specific antigen: Relevance to prostate cancer. [D] . Gilbride, Rebecca Jane. 2012

机译：galectin-3和前列腺特异抗原之间的分子相互作用：与前列腺癌的相关性。
6. High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 45-dimethoxy-2-nitrobenzaldehyde [O] . Hak-Bong Kim, Mi-Ju Kim, Dae-Young Kim, 2011

机译：来自人前列腺和结肠癌细胞的转移细胞对TRAIL的高度敏感性以及45-二甲氧基-2-硝基苯甲醛对TRAIL不敏感的原代细胞对TRAIL的敏感性
7. CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer. [O] . Roux, Stephan, Apetoh, Lionel, Chalmin, Fanny, 2008

机译：在结肠癌的啮齿动物模型中，CD4 + CD25 + Treg可控制肿瘤浸润DC的TRAIL依赖性细胞毒性。

Modulation of TRAIL Cytotoxicity by Amiloride in Prostate Cancer.

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