JP-8 Jet Fuel: Genotoxic and Cytotoxic Studies in Experimental Animals

摘要

Genotoxicity is often linked to carcinogenesis. The assessment of the genotoxic potential of any 'agent' is important in terms of suggesting its carcinogenic potential. Hence, the evaluation of the genotoxic potential of jet fuels, JP-8 and Jet-A has been proposed in these investigations. The rodent micronucleus (MN) assay, which detects micronuclei, arising from both chromosomal fragments and unequal segregation of chromosomes during cell division has been widely applied as an in vivo assay for detecting genotoxic agents. The assay became a standard test system for genotoxicity evaluations in regulatory agencies in several countries (Sofuni 1993, Kirkland 1993, Auletta et al., 1993, Health Protection Branch Genotoxicity Committee, Canada, 1993).