TREATMENT OF TOXOPLASMOSIS

摘要

1) Since last year, screening tests of various kinds of compounds were continuously performed for the purpose of obtaining new and effective drugs against toxoplasmosis. Compounds tested during this year's period were 14 pyramiding derivatives, 17'triazine derivatives 9 sulfon-amide derivatives, 2 thiourea derivatives, 1 purine derivative, and 1 guanidine derivative. All of these compounds, administered per orally, were found to have no effect on experimental toxoplasmosis in mice, because the treated mice survived only as long as their controls. By intraperitoneal administration, three sulfone derivatives had been shown to have antitoxoplasmic activities. In this study, these compounds were used per orally, resulting in prolongation of the period of survival up to 40 days in some cases. These compounds were 4-Nitro-4'-formylamino-diphenylsulfone, 4-Nitro-4'-amino-diphenylsulfone, and 4-Nitro-4'-acetoajnino-diphenylsulf one.n2) By oral administration, the effects of Spiramycine and pyridazine were evaluated on experimental toxoplasmosis in mice, and compared with those of pyrimethamine, Spiramycine or pyridazine, when used alone, showed a slight killing effect on the parasite, although the survival period of the mice was considerably prolonged. Combined use of these two drugs proved highly -effective following oral administration of 13 mg each per mouse, if given immediately after infection and for 21 days. The 2 strains of Toxoplasma used, Beverley and RH, did not show any differences in susceptibility to these drugs, but this might be due to the fact that relatively enormous dosages of the drugs were administered.