Investigation of Prognostic Ability of Novel Imaging Markers for Traumatic Brain Injury (TBI).

摘要

This is the third annual report for the award made on September 15, 2008. Since the last report the above study has recruited 72 patients. Thirty six of these patients completed their one month scan, 25 completed their 6 month scan an d2 completed their 18 month scan. Since the last annual report, the IRB protocol went through additional modifications, mainly to streamline the process of recruitment of moderate and severe patients into the study. Currently we have screened over 300 patients that have been admitted to the Shock Trauma Center. At this point the recruitment process is smooth although there are some challenges in the recruitment of the severe patients within the first 10 days of injury. Several presentations were made at international meetings mainly on the resting state data which clearly show a decrease in the default mode network among the mildly injured patients that seem to take as long as 6 months to recover to the control levels. A manuscript of retrospective analysis of severely injured TBI patients to determine whether DTI parameters would be predictive of their outcomes has now led to a full manuscript which is being submitted to the Journal of Neurotrauma injured patients.