A Dynamic Flow Gassing Chamber for Toxicology Studies with Special Reference to Its Use with NO2

摘要

To test the toxicity of nitrogen dioxide/nitrogen tetroxide and other gases, it was necessary to construct an exposure chamber for small laboratory animals. This report describes the construction and operation of a small dynamic flow gassing chamber for studying toxic gas inhalation. Special attention is given to its use with NO2/N2O4 and the system for monitoring the concentration of gas. Several accessories for the chamber include a special harness for monitoring chest sounds of the subjects being gassed; a system for endotracheal intubation for allowing the subject to breathe the gas concentration while being manipulated surgically outside the chamber; and, a small 'by-pass' chamber for small laboratory animal species being utilized in timed-dose studies. (Author)