The Chemotactic Properties of the Products of Collagenolysis

摘要

During the course of studies of the chemical kinetics of necrotic wounds, it was noticed that tissue collagenolysis preceeded the infiltration of the wound by polymorphonuclear leukocytes (PMN). Further, the early studies of Spector, suggested that peptides produced by the proteolytic degradation of various proteins all produced leukocyte emigration if they were between 5 to 14 amino acid residues in size. Therefore, possibly the degradation products of collagen that were most probably released during collagenolysis from the necrotic wound might also be involved in the PMN infiltration so characteristic of inflammation. This paper demonstrates the in vivo leukotactic properties of these product peptides released by the activity of this cutaneous collagenase from native soluble collagen.