Double Heterozygosity for Hemoglobin Camden (beta 131 Gln Yields Glu) and Hemoglobin S in an American Negro.

摘要

A hemoglobin variant with the slightly fast mobility associated with K hemoglobin was found, together with hemoglobin S, in an apparently healthy 3-year-old Negro girl from Washington, D. C. Her father had the same variant, along with hemoglobin A, and her mother had hemoglobins A+S. Respective proportions of hemoglobins K and S in the propositus were 66-34. The K variant now has been found to have the structural change Gln to Glu at position Beta 131 (Beta H9); therefore it apparently is identical to hemoglobin Camden reported in trait form in a Negro subject by Yates, Bellingham and Huehns (Nature 243: 467-468, 1973). (Author)