Absence of Hypoglycemia in Canine Splanchnic Arterial Occlusion (SAO) Shock.

摘要

The primary purpose of the present study was to determine the role of glucose in splanchnic arterial occlusion (SAO) shock. The three major arteries to the splanchnic region: celiac, superior, and inferior mesenteric of dogs were occluded for a 90 to 120 minute period. Upon release of the occlusion, shock was manifested by marked hypotension, acidosis and hemoconcentration and was 100% lethal within 120 minutes although dextran (6%) was administered during the occlusion and postocclusion period to maintain hematocrit constant. During occlusion as well as +30 to 120 minutes postocclusion blood glucose levels were found to be equal to or above control (pre-occlusion) values. Insulin remained above control levels throughout the course of shock. Results document the fact that neither hypoglycemia nor hypoinsulinemia are contributory factors in the rapid circulatory collapse leading to death in the SAO shock.