Mammalian Toxicity of Munition Compounds. Phase II. Effects of Multiple Doses. Part III. 2,6-Dinitrotoluene.

摘要

The effects of oral doses of 2,6-dinitrotoluene (2,6-DNT) after administration to dogs, rats and mice for up to 13 weeks were studied. The effects of 2,6-DNT on drug metabolizing enzymes in rats were also studied. In dogs, 4 mg/kg/day was slightly toxic; 20 mg/kg/day was very toxic and lethal to some; 100 mg/kg/day was lethal to all within 8 weeks. In rats, 7 mg/kg/day had no effects, 35 (males) or 37 (females) mg/kg/day and 145 (males) or 155 (females) mg/kg/day had dose-related toxicity. In mice, 11 mg/kg/day had no effect, while 51 (males) or 55 (females) mg/kg/day and 289 (males) or 299 (females) mg/kg/day had dose-related toxicity. Target organs included the blood (methemoglobin and sequelae), testes (depressed spermatogenesis), liver (degeneration, bile duct hyperplasia), neuromuscular system (incoordination and rigid paralysis) and kidney (degeneration). Toxic doses of 2,6-DNT in rats increased drug-metabolizing enzyme activity in rat liver. (Author)