2-Deoxy-D-Glucose Induced Hypothermia: Thermoregulatory Pathways in the Rat,

摘要

2-deoxy-D-glucose (2-DG) elicits significant and prolonged hypothermia in a variety of animals when administered either peripherally or centrally. From our current studies it would appear that in high concentrations (250mg/kg, i.p. or more) 2-DG can act directly on peripheral tissues in the rat by competitively interfering with glucose metabolism and consequently with normal heat producing mechanisms. When a low concentration of 2-DG (20micrograms) is injected centrally,the ensuing glucopenia results in vagal stimulation and subsequent diminuition of peripheral heat production. This is based on studies with atropine which demonstrated a total inhibition of the usual depression in body temperature following the administration of 2-DG into the ventral preammillary nucleus (PMV), a site normally extremely sensitive to this analogue of glucose. Additionally,from studies with PMV-lesioned rats,it was concluded that an intact nucleus is necessary for normal thermoregulation during exposure to either hot or cold environments. (Author)