Evaluation of Short-Term Bioassays to Predict Functional Impairment. Development of Cardiovascular Bioassays in Laboratory Animals/Directory of Institutions/Individuals

摘要

MITRE has been requested by the U.S. Army Medical Bioengineering Research and Development Laboratory to identify and evaluate short-term bioassays which have demonstrated ability to evaluate and predict cardiovascular impairment resulting from toxicant exposures. This directory is a companion to Selected Short-Term Cardiovascular Toxicity Tests, DAMD 17-78-C-8068, which describes the available cardiovascular testing protocols and assesses their suitability for a program. This directory catalogues the organizations currently engaged in cardiovascular bioassay utilization or development and provides information concerning specific measurements performed, test systems employed, compounds tested, requirements for anesthesia and terminal nature of the test. In the companion report, MITRE reviewed and recommended short-term tests for evaluating and predicting the functional and/or morphological impairment produced by toxic substances using animal test systems. The document presents information on the available tests for the cardiovascular system and recommends those tests which are suitable for use in a screening program.