Glomerular Dynamic Studies of the Pathogenesis of Acute Renal Failure

摘要

The aberrations in glomerular dynamic parameters attendant upon mercury induced acute renal failure have been evaluated in this study. As judged by several criteria, glomerular filtration is virtually totally abolished 16-26 hours after mercury injection. The majority of nephrons are totally collapsed and proximal tubule pressures are decidedly subnormal. The fall in glomerular filtration rate is not attributable to tubular obstruction but is directly related to alternations in pre- and postglomerular vascular resistances. The R sub A/R sub E ratio is markedly increased and probably represents preglomerular vaso-constriction concomitantly with an element of postglomerular vascular relaxation. Studies designed to determine the relative importance of this vascular change in these two vascular segments are continuing.