Brief Report on a Visit, Conference and Discussions with Dr. Everett E. Gilbert, U.S. Army Armament, Munitions and Chemical Command, Picatinny Arsenal, Dover, New Jersey on July 21, 1986 on New Synthetic Approaches to TAT

摘要

New promising ways for the synthesis of TAT have been discussed in detail, and on the base of an exchange of results obtained meanwhile both in our laboratories in Bonn and in the laboratories of Dr. Gilbert Dover NJ, numerous new experiments are to follow, which will be described also in the Fourth Interim Report (Item 0004), which follows within the next weeks. Especially, more interest should be cast on DAPT. It can be easily obtained by a procedure of E.E. Gilbert et al. Propellants & Explosives 6, 67 (1981) and references cited therein; all methods of destructing the internal methylene bridge should be studied in detail on this target molecule. Furthermore, a reaction of urea with formaldehyde is strongly suggested which should afford a carbonyl-bridged urotropine. Special interest should also be paid to a well known tetramethylene-disulfotetramine described by Hecht and Henecka, Angew.Chem. 61, 365 (1949). With the aid of trivalent phosphorus compounds (deoxygenation) or by photochemical extrusion reaction (selective excitation) transformations of this highly bioactive compound could be studied in detail; but all work on this compound must be carried out very cautiously, due to its high convulsive activity.