Immunologic Control by Oral Vaccines of Diarrheal Disease Due to Enterotoxigenic Escherichia coli and Shigella

摘要

Travelers' diarrhea in several different clinical forms represents an important source of morbidity and loss of efficiency among United States Military personnel deployed in less-developed areas of the world. The single most common recognized etiologic agent of travelers' diarrhea is enterotoxigenic Escherichia coli, while the major cause of the dysenteric form of travelers' diarrhea (i.e. accompanied by diarrheal stools with blood and mucus) is Shigella. Research carried out under this contract was aimed at developing safe and effective immunizing agents to prevent these diarrheal infections of military importance. Candidate oral vaccines against ETEC that were evaluated included purified CS1 and CS3 colonization factor fimbriae and prototype attenuated strain that expresses CS1 and CS3 fimbriae but does not elaborate LT or ST toxins. The live oral vaccine gave the best secretory IgA antifimbrial antibody response. (SDW)