Resuscitation from Hypovolemia in Swine with Intraosseous Infusion of a SaturatedSalt-Dextran Solution (SSD)

摘要

Prehospital fluid resuscitation of traumatic injury is limited by difficulty indelivering large volumes of fluid in the field and time delays associated with gaining vascular access. We addressed these limitations in 14 anesthetized swine by evaluating a highly efficient volume expander, a near saturated salt-dextran solution (SSD) administered through a new device which gains vascular access via intraosseous (IO) infusion into the sternal bone marrow. After a steady state baseline, all animals were hemorrhaged to 45 mmHg for one hr. Half of the hemorrhaged animals were then treated with a 10-30 minute Io infusion of either normal saline (NS) or SSD until cardiac output was restored to baseline. No further infusion was given and animals were monitored for 2 hrs. Both regimens