Physiological Analyses of the Afferents Controlling Brain Neurochemical Systems

摘要

Two types of experiments are described. The first was directed at theneurochemical systems that control the activity of brain serotonergic (dorsal raphe nucleus) neurons. The second examines the effects of serotonin and norepinephrine on the activity of target neurons carrying out sensory information processing or motor function. Both sets of studies utilize single unit activity in combination with multibarrel microiontophoresis in awake animals. This research program provides critical links for understanding both the control of brain neurochemical systems and the control exerted by them. This will help to elucidate, more broadly, the role of these modulatory brainstem neurochemical systems in processes such as state-dependent changes in physiology and behavior, and arousal and attention. serotonin, norepinephrine, brain, neurochemical afferents, single unit activity, microiontophoresis, glutamate, GABA, attention, arousal, bioreactivity, sleep, behavior.