Signal Transduction in T Cell Activation and Tolerance. (Reannouncement with NewAvailability Information)

摘要

T lymphocytes communicate with their environment through a large array ofspecialized cell surface receptors. These receptors provide signals which influence T cell ontogeny, activation by antigen, homing and many other aspects of T cell biology. Recent advances have provided a wealth of new information regarding the mechanism by which these surface receptors influence intracellular biochemical events. Transmembrane signaling is initiated by the binding of specific ligand to the extracellular portion of cell surface receptors. The signal is believed to be transmitted across the plasma membrane via either conformational change in the receptors, by receptor dimerization or by a change in its association with other proteins.