Metabolic Changes and Hemodynamic Dysfunction Following Hypothermic Shock.

摘要

The results of the metabolic studies suggest that while there are very large increases in circulating catecholamines, catecholamines were less sensitive in the hypothermic animals after rewarming. The heart rate was elevated almost immediately upon immersion in cold war and did not fall until 2 minutes after immersion. When the BT returned to normal (0 time) so did the heart rate, even though the catecholamine levels were very high. It would appear that the adrenergic receptors are down-regulated and seemed less sensitive. This may be the reason for lack of elevation of the FFA. However another explanation may be the 'Adipose Tissue Electronic Blanket Theory'. The changes we observed in the metabolic samples (FFA, glucose and lactate) are related to the elevation of NorEpi. When the energy bearing metabolites cannot be mobilized by catecholamines due to down-regulation and, the futile cycle of triglycerides within the adipose tissue does not produce the heat required, then the organism can no longer thermoregulate appropriately.