Anti-Emetic Drug Effects on Performance Phase 1: Laboratory Study

摘要

The objectives of this study were to evaluate the effects of two anti-emeticdrugs, granisetron ( 2 mg p.o.) and ondansetron ( 8 mg p.o.) on basic cognitive skills and complex task performance. The experimental approach, involving 24 active-duty, military subjects was a placebo controlled, double blind, crossover design with a positive control (prochlorperazine 10 mg p.o.) condition. Testing was accomplished during the evening and early morning hours, between 1630 h and 0230 h. Therefore, fatigue stemming from an extended work period and a disrupted work/rest cycle, was also part of the study design. Data were collected on: cognitive and psychomotor effects, affective state changes, temperature, serum-drug levels and side effects. The drugs of interest, granisetron and ondansetron, were extremely well tolerated and with no obvious side effects when compared to the placebo condition. Two of five cognitive tests detected a positive control effect and nearly all or the measurement instruments demonstrated a fatigue effect There was no evidence of any cognitive, psychomotor or subjective state changes caused by either granisetron or ondansetron.