Antihypertensive Effects of Total Gastrectomy on Spontaneous Hypertensive Rats

摘要

Backgrounds: Total gastrectomy (TG) played an important role in DM im-provement after curative surgery for gastric cancer (W J Surgery 2014, 58, 451-0458). The aim of the present study was to establish the effects of TG on weight loss and cardiovascular (CV) parameters in spontaneous hypertensive rats (SHR). Methods: Male SHR rats were used in the present studies. Rats were randomly assigned to either total gastrectomy (TG) or sham (Control): We measured blood pressure, heart rate, body weight and renin-aldosterone from postoperative 1 week to 12 weeks once a week for TG and Control gro,up. Results: Systolic and Diastolic Blood Pressure: TG is significantly lower compared to Control. Body Weight: TG is significantly lower compared to Control. But, there is no relationship between systolic blood pressure and body weight in TG. Renin and Aldosterone Renin and aldosterone in TG were sig-nificantly lower compared to those in control from 3 to 12 weeks. Conclusion: We demonstrated that TG lowered BP in SHR rats. Our data also showed that the beneficial effect of TG for BP was independent of weight loss in SHR rats. Our mechanistic evidence suggests that this CV benefit is likely to be the result of decreasing Renin-angiotensin-aldosterone system activities.,