Recent Developments in the Use of bis-(Trichloromethyl) Carbonate in Synthesis

摘要

As a significant substitute for the traditional chlorination reagents such as POCl3, SOCl2, phosgene, trichloromethyl chloroformate (TCF, diphosgene), bis-(trichloromethyl) carbonate (BTC, triphosgene, 1) is safer and more convenient to handle, transport, and store. Its physicochemical properties have been described in previous reviews. Recently, BTC played indispensable roles in the synthesis of important classes of organic compounds, as well as contributing significantly to reducing environmental pollution in the future. So far, BTC has been employed in various aspects of organic synthesis such as chlorination, acylation, cyclizations, ring-opening reactions, Vilsmeier reactions and dehydration reactions, etc.