Cyclocarbopalladation of alkynes: A stereoselective method for preparing dibenzoxapine containing tetrasubstituted exocyclic alkenes

摘要

A palladium-catalyzed cascade carbometalation-cross coupling of alkyne route was developed for the preparation of tetrasubstituted exocyclic alkenes with high stereo- and regiocontrol. The effectiveness of this novel methodology was demonstrated by the synthesis of a number of dibenzoxapines in sufficient quantities to support their further development.