INTRODUCTION: This cross-sectional study was performed to evaluate the effect of long-term GH substitution on leptin and ghrelin in GH deficiency (GHD). METHODS: Leptin and ghrelin were measured after glucose load for 3 h in 52 pat and 10 age- and BMI-matched healthy controls. 22 GHD pat were on GH substitution (GH-Sub) for a median of 10 yr (range 2-27 yr). 30 age- and BMI-matched GHD pat were not substituted for at least 2 yr (non-Sub). RESULTS: Basal leptin (8 microg/l (1-130) vs. 16 microg/l (3-89), p<0.05) and AUC of leptin (p<0.05) was significantly lower in GH-Sub compared to non-Sub. In the control group, leptin was higher compared to GH-Sub and similar to non-Sub (19 microg/l (4-57)). Ghrelin (baseline: non-Sub 113 ng/l (61-270), GH-Sub 145 ng/l (83-280), controls 131 ng/l (83-274)) were slightly but not significantly lower for non-Sub. After glucose load, a significant decrease in leptin appeared in both GHD groups, but not in the control group. Ghrelin decreased significantly in all groups. CONCLUSION: Lipolytic GH causes lower leptin in GH-Sub. The reason for similar ghrelin might be the compensating effect of acute GH suppression and stimulating low fat mass on ghrelin. Leptin regulation after glucose load is impaired in GHD, whereas ghrelin regulation seems to be not effected.
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机译：简介：这项横断面研究旨在评估长期GH替代对GH缺乏症（GHD）中瘦素和生长素释放肽的影响。方法：在52名患者和10名年龄和BMI匹配的健康对照者中，在葡萄糖负荷3小时后测量瘦素和生长素释放肽。 22名GHD拍子接受GH替代（GH-Sub），中位数为10年（范围2-27年）。 30岁以上和BMI匹配的GHD拍子至少2年未取代（非亚项）。结果：GH-Sub的基础瘦素（8微克/升（1-130）对16微克/升（3-89），p <0.05）和瘦素的AUC（p <0.05）明显低于非瘦素。子在对照组中，瘦素与GH-Sub相比更高，与非Sub（19 microg / l（4-57））相似。 Ghrelin（基线：非Sub 113 ng / l（61-270），GH-Sub 145 ng / l（83-280），对照131 ng / l（83-274））略低，但不显着降低子葡萄糖负荷后，两个GHD组的瘦素均显着下降，而对照组则没有。生长激素释放肽在所有组中均显着降低。结论：脂溶性GH导致GH-Sub中的瘦素降低。 ghrelin相似的原因可能是急性GH抑制和刺激低脂肪量对ghrelin的补偿作用。 GHD中葡萄糖负荷后的瘦素调节受损，而生长素释放肽的调节似乎未受影响。
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