Bimetallic copper and zinc-catalyzed oxidative cycloaddition of 3-aminopyridazines and nitriles: a direct synthesis of 1,2,4-triazolo1,5-b pyridazines via C-N and N-N bond-forming process

摘要

One-pot formation of the 1,2,4-triazolo1,5-b pyridazine nucleus and its derivatives is presented in this manuscript, in which the desired targets are offered easily via cooperative Cu(I) and Zn(II)-catalyzed tandem C-N addition and subsequent I-2/KI-mediated intramolecular oxidative N-N bond formation.