Activatable NIR-II Lanthanides-Polymetallic Oxomolybdate Hybrid Nanosensors for Monitoring Chemotherapy Induced Enteritis

摘要

Chemotherapy-induced enteritis is one of the side effects associated withcancer therapy, which significantly affects the treatment effect, but there is noeffective clinical detection method that can early diagnose its occurrence andprogression. Here, a series of second near-infrared window (NIR-Ⅱ) hybridnanosensors are designed that consisted of lanthanide nanoparticles and -Mo2C-derived polymetallic oxomolybdate nanoclusters (Ln@POM). Basedon the high sensitivity of POM to reactive oxygen species (ROS) closelyrelated to chemotherapy-induced enteritis, the NIR-II luminescence intensityand lifetime of Ln@POM (Ln: Yb~(3+), Nd~(3+), Ho~(3+), Tm~(3+), Er~(3+)) show excellentresponsiveness to H_2O_2 and HClO with the detection limit down to 0.15 and0.14 μm, respectively. Utilizing Nd@POM as a ROS-activated NIR-IInanosensor, the chemotherapeutic enteritis is successfully detected within 7 hafter induction of chemotherapy drugs, which is significantly earlier than thegold standard method (immunohistochemistry, 24 h). These resultsdemonstrate that the designed hybrid nanosensors are promising opticaltools for the early diagnosis of ROS-related diseases.