A CONVENIENT SYNTHETIC METHOD FOR FLUORINE- CONTAINING 4-ALKOXYDIHYDROBENZOb1,4DIAZEPINOLS AND 3H-BENZOb1,4DIAZEPINES BY THE REACTION OF β-TRIFLUOROACETYLKETENE ACETALS WITH 1,2-PHENYLENE-DIAMINES

摘要

β-Trifluoroacetylketene dialkyl acetals (3 and 5) reacted easily with various 1,2-phenylenediamines to give novel 4-alkoxy-2-trifluoromethyl-2,3-dihydro-1H-benzob1,4diazepinols (6 and 8) in moderate to high yields. Dehydration of 6 and 8 proceeded thermally under reduced pressure to afford the corresponding fluorine-containing 3H-benzob1,4diazepines (7 and 9).