Comparison of the antibacterial properties of phycocyanin and its SNPs and their effects on rat blood cells and liver enzymes

摘要

Background Phycocyanin is an important protein in cyanobacteria that has many medical and therapeutic properties. The aim of the present study was to compare the antibacterial properties of phycocyanin and its SNPs and to evaluate their effects on rat blood cells and liver enzymes. Results The UV absorption in phycocyanin was 620 nm but in phycocyanin nanoparticles was 420 nm. For fluorometry, the maximum emission peak of phycocyanin was 660 nm and that of phycocyanin-AgNO3 nanoparticles was 580 nm. PC-AgNp showed greater antibacterial effects than phycocyanin. In animal studies, it was found that the platelet count in both groups was higher than the control group. Red blood cells and white blood cells had changes. AST and ALT levels increased in both phycocyanin and nanoparticle groups and ALK levels decreased in both groups compared to the control group. Conclusions Examination of antibacterial activity showed that PC-AgNp showed more antibacterial effects than PC. Also, in the study of the effect of PC and NP-PC, accumulation of PC and C-Np in mice also altered blood cells and liver enzymes in rats.