Hydrophobically graded polyester polyol acrylate polymers: Synthesis, characterization, and microencapsulation of sulfamethoxazole for controlled release application

摘要

Polyester polyol macromers were prepared by using diacid-diol condensation reaction using succinic acid as the acid component and polyethylene glycol 200 (PEG 200) as the diol component. Replacing PEG 200 with increasing amounts of butanediol resulted in macromers, which upon acrylation of end hydroxy groups and polymerization resulted in polymers with graded hydrophobicity depending on the amount of butanediol present in the polymer. These polymers showed expected trends in water equilibrium swells, equilibrium water contact angles, and in vitro degradation times depending on the amount of modification with butanediol. These polymers were used to microencapsulate sulfamethoxazole as a model drug and the in vitro delivery of the drug also followed the expected trend depending on the polymer hydrophobicity. Thus, it was shown that it is possible to prepare polyesters of graded properties by judicious selection of diacids and diols. (c) 2006 Wiley Periodicals, Inc.