Surface Modification Using Self-Assembled Layers of Amphiphilic Cyclodextrins

摘要

In this study six amphiphilic cyclodextrin derivatives were prepared by esterification and used to coat five industrial products made from polypropylene, polyethylene, polyvinyl chloride, or polyurethane using a new, patented coating technology. This simple approach, which consists merely of dipping the material to be coated into a suspension of a given cyclodextrin derivative in an ethanol/water solution, was used to functionalize support materials with a coat that is stable in aqueous solutions and which renders the coated materials hydrophilic. The functionalization proved to be controllable in terms of amount of cyclodextrin on the surface and can be implemented in existing production lines without investment in advanced production equipment. It is hypothesized that the cyclodextrins order themselves in structured layers forming channel-like structures preserving the very large potential for uptake and release of active compounds that is known to cyclodextrins.