Persistence of TNFalpha in diabetic wounds.

摘要

To the Editor: In the February issue of Diabetologia, Graves and colleagues 1 have shown that TNFalpha concentrations were elevated in the wounds of mice used as a model of diabetes compared with normoglycaemic litter-mates and that TNFalpha drove fibroblast apoptosis, hence impairing wound healing. In their study, anti-TNF treatment increased fibroblast density and improved wound healing. Of course, the usual caveat applies to such animal studies (the authors used streptozotocin-induced and db/db models of type 1 and type 2 diabetes, respectively) regarding whether they are relevant to human disease, but the results of Siqueira et al. 1 are in close agreement with observations we have made in a human model of dermal wound healing employing cantharidin skin blisters.