Comparative Delivery of Diltiazem Hydrochloride Through Synthesized Polymer: Hydrogel and Hydrogel Microspheres

摘要

In this study, interpenetrating polymer network (IPN) hydrogel based on polyvinyl alcohol (PVA) networking with polyacrylic acid (PAA) were prepared by a non-conventional emulsion method without any addedcrosslinker, using benzoyl peroxide as initiator and sodiumchloride (NaCl) as additive. The IPN hydrogel wascharacterized by using Fourier transformed infrared (FTIR)spectrophotometry, Thermo gravimetric analysis (TGA),and Scanning electron microscopy (SEM). (PVA-co-PAA)/NaCl normal IPN hydrogel (H) were fabricated intohydrogel microspheres (HM) by modified emulsion crosslinkingmethod using glutaraldehyde-saturated toluene ascrosslinker and were loaded with Diltiazem hydrochloride(DL). The IPN hydrogel showed more swelling in simulatedintestinal fluid (SIF). (PVA-co-PAA)/NaCl HM formulationA1 showed comparatively higher DL entrapment(79) and better control over DL release up to 24 h. Bycomparing antihypertensive activity of DL loaded two formulationsin normotensive rats, HM formulation A1 foundmore effective in reducing blood pressure to 40.1. Theexperimental results demonstrated that (PVA-co-PAA)/NaCl HM had the greater potential than normal hydrogelto be used as a drug carrier. A single use of the preparedhydrogel microsphere system of DL can effectively controlhypertension in rats. The system holds promise for clinicalstudies.