A CONCISE SYNTHESIS OF 6,7-DIHYDRO-5H-DIBENZc,eAZEPIN-5-ONE

摘要

A concise and efficient strategy for the synthesis of dibenzc,eazepin-5-ones has been developed. The approach relies on a key transformation involving Suzuki-Miyaura coupling of 2-bromobenzyl azides with 2-(methoxycarbonyl)phenylboronic acid, followed by either a stepwise sequence involving Staudinger reaction and lactam formation or one-pot hydrogenation/base-mediated intramolecular lactam formation.