Neural silences can be localized rapidly using noninvasive scalp EEG

摘要

A rapid and cost-effective noninvasive tool to detect and characterize neural silences can be of important benefit in diagnosing and treating many disorders. We propose an algorithm, SilenceMap, for uncovering the absence of electrophysiological signals, or neural silences, using noninvasive scalp electroencephalography (EEG) signals. By accounting for the contributions of different sources to the power of the recorded signals, and using a hemispheric baseline approach and a convex spectral clustering framework, SilenceMap permits rapid detection and localization of regions of silence in the brain using a relatively small amount of EEG data. SilenceMap substantially outperformed existing source localization algorithms in estimating the center-of-mass of the silence for three pediatric cortical resection patients, using fewer than 3 minutes of EEG recordings (13, 2, and 11mm vs. 25, 62, and 53 mm), as well for 100 different simulated regions of silence based on a real human head model (12 +/- 0.7 mm vs. 54 +/- 2.2 mm). SilenceMap paves the way towards accessible early diagnosis and continuous monitoring of altered physiological properties of human cortical function. Chamanzar et al. demonstrate that an algorithm, 'SilenceMap', results in rapid detection and localization of neural silences using just a few minutes of noninvasive scalp electroencephalography (EEG) recording. SilenceMap vastly outperformed existing algorithms in accuracy of localizing silences in human participants with circumscribed cortical resections, indicating its potential use for the monitoring of cortical function and health.