COMPARISON OF WIDAL AND TYPHOID IgM AND IgG IN RAPID AND EARLY DIAGNOSIS OF ENTERIC FEVER

摘要

ABSTRACT: OBJECTIVE : Typhoid fever is one of the major public health problems indeveloping countries including India. A simple, reliable, rapid and early diagnostic test has been one of the important needs of the clinicians.Thepresent study was carried out to compare the Widal test and Typhoid IgM IgG Rapid test in diagnosing of Salmonella typhi infection. METHODS: 100 cases having clinical suspicion of typhoid fever and 40 controls (20 healthy persons and 20 non- typhoidal febrile patients) were studied. Subjects were investigated by blood culture, Clot culture,Widal test and Typhoid IgM IgG Rapid test and the results were compared RESULTS: Typhoid IgM IgG test was positive for IgM in 70cases IgG for 6 cases of typhoid fever compared to widal which showed only 58 positive cases. The sensitivity, specificity, positive andnegative predictive value of Typhoid IgM was found as 70, 90, 94.59 and 54.55 respectively. On the other hand corresponding values for Widal test were of 58, 85, 90.63 and 44.74 respectively. CONCLUSION: In the present study, the Typhoid IgM IgG yielded remarkable high sensitivity and specificity to diagnose typhoid fever in the first week of illness, so it is recommended to use the test in small and less equipped laboratories as a complementary test to Widal.