Study on the Correlation between Syndrome Differentiation of Malignant Pleural Effusion Treated by External Treatment of Traditional Chinese Medicine and Immunohistochemistry of Biopsy Tissue Based on Medical Video-assisted Thoracoscope

摘要

Objective: Guided by the theory of syndrome differentiation of yin and yang in traditionalChinese medicine surgery, through visual observation of internal medicine thoracoscope, comprehensive observation of pleural cavity and immunohistochemistry of biopsy tissue, toclassify malignant pleural effusion according to syndrome differentiation, and to explore thescientific nature of its theory. Methods: From March 1, 2014 to February 28, 2015, 40 cases of malignant pleural effusion were treated in Beijing Chaoyang Hospital affiliated to CapitalMedical University. According to the proposed TCM diagnostic criteria for yin and yangsyndrome differentiation, and collect age, gender, course of disease, clinical symptoms, tumor primary focus, histomorphological manifestations and immunohistochemical results and other related information, and carry out statistical data processing. Results: The positive syndrome was mainly metastatic lung adenocarcinoma, which accounted for the majority of all MPE cases, up to 75. The immunohistochemical results of biopsy tissues were mainly CEA and TTF-1 positive; While pleural effusion caused by pleural mesothelioma was the main type of yin syndrome, and the results of immunohistochemistrycombined with biopsy were mainly positive for D2-40, Calretinin, WT-1 and CK5/6. Conclusion: TCM syndrome differentiation of MPE based on internal thoracoscopycombined with biopsy immunohistochemical results has sufficient theoretical basis andcertain scientific nature, and further clinical research is needed to verify its effectiveness andpracticability in the future.