Machine Perfusion of Donor Heart: State of the Art

摘要

Purpose of Review The purpose of this manuscript is to briefly review the past, present, and potential future of machine perfusion (MP) of the donor heart and to highlight its potentials to improve heart transplantation rates and outcomes. Recent Findings During the last few decades, the interests in MP has been raised. Experimental studies in animal and human models, together with clinical trials have provided robust evidence that MP may be considered as a better organ preservation method compared to conventional cold storage, as it avoids cold ischemia and maintains aerobic metabolism requirements of the donor heart. Evidence suggest that the dynamic platform in MP may offer an avenue to deliver reconditioning therapies during the preservation time. MP can preserve the donated heart in a beating, semi-physiologic dynamic status. It allows functional and metabolic evaluation, and reconditioning of dysfunctional donated hearts, and therefore may hold promise to expand the donor pool.