Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET

摘要

Purpose To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB). Methods We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively healthy adults (age range, 50-70 years) using automated quantification. The standardized uptake value ratios (SUVRs) of F-18 FBB were calculated for predefined regions by normalizing the regional count with cerebellar cortex. Results The distribution of amyloid beta for each brain region revealed no age-related trends (p >0.05). From all subjects, mean SUVR of amyloid deposit was 1.30 +/- 0.18. The right parietal lobe showed the highest SUVR value (1.46 +/- 0.23), whereas the right frontal lobe and left precuneus showed the lowest SUVR (1.23 +/- 0.25). Conclusions We provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer's disease.