Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P < 5 x 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
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机译：肺功能措施用于诊断慢性阻塞性肺疾病。在38199名欧洲血统的个体中，我们研究了1000个基因组计划（第1期）影响的基因型在1 s（FEV1），强制肺活量（FVC）和FEV1 / FVC的全基因组关联，并追踪了54,550欧洲人。我们在ENSA，RNU5F-1，KCNS3，AK097794，ASTN2，LHX3，CCDC91，TBX3，TRIP11，RIN3，TEKT5，LTBP4，MN1和AP1S2或附近确定了14个新基因座（P <5 x 10（-8））在已知位点NPNT和GPR126上的两个新信号，为重新了解这些性状和改变其的肺部疾病的遗传决定因素提供了基础。
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