Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study

摘要

abstract_textpObjective: To compare the clinical effectiveness of the triple intraarticular injection of platelet-rich plasma (PRP) with respect to the single injection in patients with mild osteoarthritis of the knee./ppMethods: A total of 35 patients with a clinical and radiographic diagnosis of osteoarthritis grade I and II (according to Kellgren-Lawrence radiological scale) were analyzed. They were randomized into two groups: single application (18 patients) and triple application (17 patients). Both groups were evaluated using the Visual Analogue Scale (VAS), the Western Ontario and Mc-Master Universities (WOMAC) index, and the Health Survey 12v2 (SF-12) at baseline and at 6, 12, 24, 36 and 48 weeks post-treatment./ppResults: Both treatments significantly decreased the level of pain (VAS) (single, from 7.3 +/- 2.1 to 4.6 +/- 2.7 and triple, from 6.6 +/- 2.4 to 0.9 +/- 1.4; p 0.05) and the total WOMAC (single, from 44.2 +/- 19.7 to 26.7 +/- 24.9 and triple, from 41.4 +/- 15.5 to 7.2 +/- 7.3; p 0.05) at the end of the study. The triple application showed better improvement in the VAS (p=0.0007) and the total WOMAC (p=0.0209) scores when comparing the final results between groups./ppConclusion: The triple injection of PRP in patients with mild knee osteoarthritis is clinically more effective than the single application at 48 weeks of follow-up./p/abstract_text