Antimicrobial activity of some new O-acyloximino-dibenzob,ethiepins and O-acyloximino-dibenzob,ethiepin-5,5-dioxides against planktonic cells

摘要

In the search of bioactive molecules, a series of O-acyloximino-dibenzob,ethiepins and O- acyloximino-dibenzob,ethiepin-5,5-dioxides have been synthesized in several stages, obtaining O- acyl-oximino-dibenzob,ethiepins 1. The sulfones 2 were obtained by the oxidation of O-acyloximino- dibenzob,ethiepins 1 with hydrogen peroxide in acetic acid, at boiling temperature. The new compounds were characterized by spectroscopic data and elemental analyses and were evaluated for their antimicrobial activities. The tested compounds exhibited specific antimicrobial activity against different bacterial and fungal strains, recently isolated from clinical samples and exhibiting resistance features to conventional antibiotics, with MIC values ranging from 1000 to 15.6 ug/mL.