Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy

摘要

Background: Major trauma is a leading cause of morbidity and mortality worldwide with hemorrhage accounting for 40 of deaths. Acute traumatic coagulopathy exacerbates bleeding, but controversy remains over the degree to which inhibition of procoagulant pathways (anticoagulation), fibrinogen loss, and fibrinolysis drive the pathologic process. Through a combination of experimental study in a murine model of trauma hemorrhage and human observation, the authors' objective was to determine the predominant pathophysiology of acute traumatic coagulopathy.