Formulation and evaluation of floating in situ gelling system of losartan potassium

摘要

The present investigation deals with the formulation and evaluation of sodium alginate and pectin based In situ gel of Losartan Potassium. Sodium alginate and guar gum were used as a polymer and CaCO3 was used as a crosslinking agent. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultra-violet irradiation, from which drug gets released in sustained and controlled manner. The objective of this study was to develop a novel in- situ gel. The system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific Physico-chemical parameters. In-situ gel was formed at a biological pH. In vitro release studies were conducted in simulated gastric fluid and cumulative amount of drug release was analyzed by spectrophotometry. From designed set of experiments, it was evident that formulation containing 2 of sodium alginate and 1.5 of Guar gum control the release of drug for longer duration. The in-situ gel exhibited the expected, viscosity, drug content, pH, in vitro gelling capacity, in vitro floating ability and sustained drug release. The drug release from the in situ gels follows the Fickian diffusion type of release.