DIVERSITY-ORIENTED SYNTHESIS OF SUBSTITUTED PYRAZOLO-4,3-d1,2,3TRIAZIN-4-ONES

摘要

An efficient synthesis of 3,7-disubstituted 3,5-dihydro-4H-pyrazolo-4,3-d1,2,3triazin-4-ones(2),especially suited for late-stage decoration,is described.Diverse 3-benzyl analogs were obtained by amidation-cyclization in one pot and various pyrazolotriazinone-7-bromides were employed in Suzuki and Sonogashira cross-coupling reactions.