Protective Effects of CYP2E1 Inhibitors on Metabolic Syndrome-induced Liver Injury in Guinea Pigs

Volodymyr V. Rushchak; Ganna M. Shayakhmetova; Anatoliy V. MatvienkoMykola O. Chashchyn

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Protective Effects of CYP2E1 Inhibitors on Metabolic Syndrome-induced Liver Injury in Guinea Pigs

机译：CYP2E1抑制剂对豚鼠代谢综合征诱发肝损伤的保护作用

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摘要

The present work reports the effects of CYP2E1-inhibitors (quercetin, 4- methylpyrazole and disulfiram) on the indices characterizing state of the liver in guinea pigs with metabolic syndrome (MS) induced by protamine sulfate repeated administrations.

机译：本研究报道了CYP2E1抑制剂（槲皮素、4-甲基吡唑和双硫仑）对硫酸鱼精蛋白诱导的代谢综合征（MS）豚鼠肝脏状态表征指标的影响。

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来源
《Biotechnology Journal International》 |2015年第2期|57-67|共11页
作者
Volodymyr V. Rushchak; Ganna M. Shayakhmetova; Anatoliy V. MatvienkoMykola O. Chashchyn;
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作者单位

Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics, NAS of Ukraine;

Department of General Toxicology, SI “Institute of Pharmacology and Toxicology, NAMS of Ukraine”;

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正文语种英语
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关键词
CYP2E1; metabolic syndrome; diabetes; oxidative stress; protamine sulphate;

机译：CYP2E1;代谢综合征;糖尿病;氧化应激;硫酸鱼精蛋白;

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1. Metabolic TV‐oxidation of atropine, hyoscine and the corresponding nor‐alkaloids by guinea‐pig liver microsomal preparations [J] . J. D. Phillipson, S. S. Handa, J. W. Gorrod journal of pharmacy and pharmacology . 1976,第9期

机译：Metabolic TV‐oxidation of atropine, hyoscine and the corresponding nor‐alkaloids by guinea‐pig liver microsomal preparations
2. Inducible Nitric Oxide Synthase Expression in Liver Injury: Liver Protective Effects on Primary Rat Hepatocytes. [J] . Masaki Kaibori, Tadayoshi Okumura, Kenji SatoMikio NishizawaMasanori Kon Inflammation & allergy drug targets . 2015,第2期

机译：Inducible Nitric Oxide Synthase Expression in Liver Injury: Liver Protective Effects on Primary Rat Hepatocytes.
3. Role of non‐parenchymal liver cells in ischaemia‐reperfusion liver injury: protective effects of muramyl dipeptide [J] . Jean Gugenheim, Francesco Crafa, Giovanni DammerotaAlberto EvangelistaMarie‐Christine Saint‐PaulChantal CavanelFrangoise LapalusJean Mouiel transplant international . 1994,第1期

机译：Role of non‐parenchymal liver cells in ischaemia‐reperfusion liver injury: protective effects of muramyl dipeptide

Protective Effects of CYP2E1 Inhibitors on Metabolic Syndrome-induced Liver Injury in Guinea Pigs

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