NUCLEOPHILIC SUBSTITUTION REACTIONS ON INDOLE NUCLEUS: FORMATION OF (3a,8a-cis)-1,2,3,3a,8,8a-HEXAHYDROPYRROLO-2,3-bINDOLES HAVING A SUBSTITUENT AT THE 3a-POSITION1

摘要

Various nucleophiles, such as indole, 1,2,3-trimethoxybenzene, anisole, phenol, and pyrrole, reacted with 1-hydroxy-Nb-trifluoroacetyltryptamine under the presence of mesyl chloride to give novel series of (3a,8a-cis)-1,2,3,3a,8,8a-hexahydropyrrolo2,3-bindoles having a substituent at the 3a-position. Their structures and by-products were strictly determined.