CATALYTIC INTRAMOLECULAR 2+2+2 CYCLOADDITION OF PEPTIDE-TETHERED BRANCHED TRIYNES FOR THE SYNTHESIS OF CYCLIC PEPTIDES

摘要

Rhodium-catalyzed intramolecular 2+2+2 cycloaddition of peptide-tethered branched triynes gave cyclic peptides in moderate to excellent yields. This is a new catalytic protocol for the synthesis of cyclic peptides containing various amino acids.