Phytochemical evaluation and Analgesic activity of fresh juice of young stem (tender) bark of Azadirachta indica A. Juss

摘要

The aim of present study was to assess the phytochemical evaluation and analgesic activity of fresh juice of young stem (tender) bark of Azadirachta indica A. Juss. The fresh juice of young stem bark of Azadirachta indica was collected and dried under Lyophilizer and fresh extract can be obtained. The fresh juice of young stem bark of Azadirachta indica was studied for its in-vivo analgesic activity by using the Eddyrsquo;s hot plate method And Heat conduction method response in rats. The time course study was performed to find the peak time for the maximum analgesic activity. The effective dose of the extract for analgesic activity was calculated from doseresponse curve by using the Eddyrsquo;s hot plate method And Heat conduction method response in rats. In both of the cases diclofenac sodium was used as standard drug. In both of Eddyrsquo;s hot plate method And Heat conduction method response in rats writhing response method; the intraperitoneal administration of fresh juice of young stem (tender) bark of Azadirachta indica A. Juss (200mg/kg, 300 mg/kg and 500 mg/kg) induced a significant analgesic activity in a dosedependent manner respectively. The plant may have the phytoconstituents which inhibit cyclooxygenase enzyme or act on central opioid receptors.