Side effects of non-steroidal anti rheumatic drugs: A survey in Austria

摘要

abstract_textpObjective: Gastrointestinal side effects are the limiting factor in the prescription of non-steroidal antirheumatic drugs (NSAID). However, there are no recent data from Austria. The aim of this prevalence study was therefore to assess the gastrointestinal risk from NSAID in Austria./ppMethods: A total of 1347 patients were observed in an outpatient setting between March 2000 and February 2001. Side effects from NSAID were documented by questionnaire at two time points with a mean interval of 31 days./ppDocumented data were analysed descriptively using an explorative strategy. The prevalence of side effects was compared to data from literature./ppResults: Side effects were reported by 18.1 of the patients, severe gastro-intestinal complications (ulcer, bleeding, perforation) were diagnosed in 0.7. Prescription of effective GI-protection (proton pump inhibitors, misoprostole, famotidin in high dose) was seen in only one third of the patients at risk./ppConclusion: The prevalence of severe gastrointestinal side effects by NSAIDs assessed in our study was clearly lower than the prevalence reported in the Anglo-American literature. This may be due to a different prescription behaviour: about 75 of the patients took Diclofenac, lbuprofen or Meloxicam, drugs which have a very low potential of gastrointestinal complications. However, more information for general practitioners is needed yet to sufficiently protect patients at gastrointestinal risk from NSAID./p/abstract_text